"American Pop" is the animated story of a very talented and troubled family starting with 19th century Russia and moving through several generations of musicians. The film covers American music from the pre-jazz age through soul, '50s rock, drug-laden psychadelia, and punk, finally ending with the onset of new wave in the early 1980s.

Corky, a lesbian ex con hired to work in an apartment as a plumber, meets neighbors Caesar, who launders money for the Mafia, and his girlfriend Violet. The two women have a love affair and decide to steal $2,000,000 that Caesar has in custody before he gives them back to Mafia boss Gino Marzone. Caesar is set up by the two scheming women as a scapegoat but things start to go wrong when he reacts in an unexpected way...